s/l triglusovil protein antibody positive
Posted By: me on 2008-07-22
In Reply to:
Subject: s/l triglusovil protein antibody positive
anti-smooth muscle antibody positive and s/ltriglusovil protein antibody positive.
This is the spleen lab tests. Any ideas?
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Doc says, "pt has hx of abnormal protein S, (s/l) CNN, and possible lipid antibody, all three. Hx of DVT in 2001. She had pulmonary embolus in June at which time she had Factor V difficiency. She has multiple coagulopathies." Any help appreciated.Thx. mmw
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Protein S is a vitamin K–dependent anticoagulant protein, thus low levels tend to
Subject: Protein S is a vitamin K–dependent anticoagulant protein, thus low levels tend to
increase the tendency for coagulation/DVT. In this regard, I agree with you.
However, maybe the elevation of protein S at the time of the DVT rules out protein S deficiency as a probable cause of the thrombotic episode. Is there any such implication? The clotting mechanism involves a complex cascade of activation events of numerous factors, and Protein S is just one cofactor for another anticoagulant protein.
Still, it would be wise to flag the doctor and let him put the final word.
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